The scientific article "Serial Systemic Immune Inflammation Indices: Markers of Acute Migraine Events or Indicators of Persistent Inflammatory Status?" was published in the international refereed journal "The Journal of Headache and Pain".

The author of the paper is Leila Karim (Doctor of Psychology and Public Health Care), Professor of Caucasus University and RMIT University (Melbourne, Australia).

See the link to the article.

Tissa Wijeratne, Melanie J. Murphy, Chanith Wijeratne, Paolo Martelletti, Leila Karimi, Vasso Apostolopoulos, Carmela Sales, Nina Riddell, Sheila G. Crewther. Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status? (2025) The Journal of Headache and Pain, 25 (7). See the link. 

The journal „The Journal of Headache and Pain” is indexed the SCOPUS-ის (Elsevier) international scientific database, with a CiteScore of 11.8, labeled as A level.

Link.

Migraine is the most common complex neurological disorder, affecting over a billion people worldwide. Neurogenic inflammation has long been recognized as a key factor in the pathophysiology of migraine. the primary aim of the study was to explore the potential clinical utility of the Serial Systemic Immune-Inflammatory Indices (SSIIi) as a comparative measure of duration and severity of inflammation in migraine patients with aura and no-aura both within an acute inpatient setting and as outpatients.

The study was conducted on 186 inpatients with migraine. The study showed that the level of SSIIi was significantly lower in patients with migraine with aura compared with those with migraine without aura. There was a significant decrease in SSIIi in patients with migraine with aura, while SSIIi remained consistently high in migraine patients without aura and in the control group. The data in the control group are similar to those in migraine patients without aura, suggesting that systemic inflammation may be persistent in some migraine patients. The findings highlight the need to study the pathophysiology, chronicity, and progression of migraine to better understand the role of inflammation in the different phases of migraine.

Institute of Health Care Policy, Caucasus University.